منابع مشابه
Nicotinic modulation of descending pain control circuitry.
Along with the well-known rewarding effects, activation of nicotinic acetylcholine receptors (nAChRs) can also relieve pain, and some nicotinic agonists have analgesic efficacy similar to opioids. A major target of analgesic drugs is the descending pain modulatory pathway, including the ventrolateral periaqueductal gray (vlPAG) and the rostral ventromedial medulla (RVM). Although activating nAC...
متن کاملItch and pain.
The discovery of a specialized neuronal pathway for itch has markedly improved our understanding of itch processing under physiological conditions. However, the complex interactions of pain and itch are only partly understood. This review focuses on the neurophysiological mechanisms involved in clinical and experimental itch conditions. There is emerging evidence that similar patterns of periph...
متن کاملItch and pain.
Decades of pain research have succeeded in elucidating complex mechanisms of acute activation and chronic sensitization of nociceptors leading to pain. In contrast, itch conditions have received less attention and even basic mechanisms for the induction of itch are still unclear. In this review we describe itch-specific pathways, but also evidence for a modified pattern theory of pruritus offer...
متن کاملDescending control of pain.
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling) information from the viscera, skin and other organs is subject to extensive processing by a diversity of mechanisms, certain of which enhance, and certain of which inhibit, its transfer to higher centres. In this regard, a network of descending pathways projecting from cerebral structures to the DH plays a co...
متن کاملDescending control of pain.
Thanks largely to the study of the brainstem nuclei that mediate stimulation analgesia, the involvement of the monoamines in the descending control of pain is now well established. The periaqueductal grey, the raphe nuclei (NRM and DRN) and the locus coeruleus are all key brainstem sites for the control of nociceptive transmission in the spinal cord. Although the initial emphasis was on 5-HT as...
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ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.072